韩小瑜,博士、教授，1981年5月出生于山西灵石。毕业于新加坡国立大学，获理学博士学位。2012年-2014年，在新加坡国立大学从事博士后研究工作。2014年3月回国工作。主要研究方向为有机合成、药物合成、不对称催化及制药工艺研究。其首次报道的手性二肽膦催化剂由于其高效的催化效率以及广泛的应用范围已被日本东京化成（TCI）试剂公司商业化,市场前景可观。已在包括J.Am.Chem.Soc(美国化学会志，IF= 12.113),Angew.Chem.Int.Ed.(德国应用化学，IF=11.261)等国际顶级及权威期刊在内的刊物上发表SCI论文20余篇。获得了包括浙江省钱江人才计划、我校青年英才、新加坡国立大学最佳论文奖、国家优秀自费留学生奖及爱思唯尔博士奖在内的诸多荣誉及奖项。目前主持国家自然科学基金及浙江省自然科学基金项目各一项。

代表性成果
1. Han, Xiaoyu*; Chen Fenfen; Ye Can; Wang Yongjiang* “Enantioselective Conjugate Addition of Azlactones to Nitroolefins with a Thiourea-Based Bifunctional Organocatalyst”, Synlett 2017, doi 10.1055/s-0036-1588942. (IF=2.419)
2. Wang, Tianli; Han, Xiaoyu; Zhong, Fangrui; Yao, Weijun; Lu, Yixin* “Amino Acid-Derived Bifunctional Phosphines for Enantioselective Transformations”, Acc. Chem. Res. 2016, 49, 1369. (IF=22.003)
3. Han, Xiaoyu*; Chan Wai-Lun; Yao Weijun; Wang Yongjiang; Lu, Yixin* “Phosphine- mediated Highly Enantioselective Spirocyclization with Ketimines as Substrates”, Angew. Chem. Int. Ed. 2016, 55, 6492. (IF=11.261)
4. Han, Xiaoyu*; Ni, Huanzhen; Chan, Wai-Lun; Gai, Xikun; Wang, Yongjiang; Lu, Yixin* “Highly Enantioselective Synthesis of Dihydrocoumarin-fused Dihydropyrans via the Phosphine-catalyzed [4+2] Annulation of allenones with 3-Aroylcoumarins” Org. Biomol. Chem. 2016, 14, 5059. (IF=3.562)
5. Han, Xiaoyu*; Gai, Xikun；Wang, Yongjiang; Zeng, Xiaofei* “Highly Enatio- and Diaster- eoselective L-Proline Derived Acetyl-glucose Amide Catalyzed Aldol Reaction of Ketones to Aldehydes under Solvent-free Conditions” Synlett 2015, 26, 2858. (IF=2.419)
6. Han, Xiaoyu; Yao, Weijun; Wang, Tianli; Tan, Yong Ren; Yan Ziyu; Kwiatkowski, Jacek; Lu, Yixin* “Asymmetric Synthesis of Spiropyrazolones via Phosphine- catalyzed [4+1] Annulation”, Angew. Chem. Int. Ed. 2014, 53, 5643. (IF=11.261)
7. Han, Xiaoyu; Zhong, Fangrui; Wang, Youqing; Lu, Yixin* “Versatile Enantioselective [3+2] Cyclization between Imines and Allenoates Catalyzed by Dipeptide-Based Phosphines”, Angew. Chem. Int. Ed. 2012, 51, 767. (IF=11.261)
8. Han, Xiaoyu; Wang, Youqing; Zhong, Fangrui; Lu, Yixin* “Enantioselective [3+2] Cycloaddition of Allenes to Acrylates Catalyzed by Dipeptide-derived Novel Phosphines: Facile Creation of Functionalized Cyclopentenes Containing Quaternary Stereogenic Centers”, J. Am. Chem. Soc. 2011, 133, 1726. (IF=12.113)
9. Han, Xiaoyu; Wang, Youqing; Zhong, Fangrui; Lu, Yixin* “Enantioselective Morita- BaylisHillman Reaction Promoted by L-Threonine-Derived Phosphine Thiourea Catalysts”, Org. Biomol. Chem. 2011, 9, 6734. (IF=3.562)
10. Han, Xiaoyu; Wang, Su-Xi; Zhong, Fangrui; Lu, Yixin* “Formation of Functionalized Cyclopentenes via Catalytic Asymmetric [3+2] Cycloaddition of Acrylamides with Allenes Promoted by Dipeptide-derived Phosphines”, Synthesis 2011, 1859. (IF=2.689)
11. Zhong, Fangrui; Han, Xiaoyu; Wang, Youqing; Lu, Yixin* “Highly Enantioselective [4+2] Annulations Catalyzed by Amino Acid-Based Phosphines: Synthesis of Functionalized Cyclohexenes and 3-Spirocyclohexene-2-oxindoles”, Chem. Sci. 2012, 3, 1231. (IF=9.211)
12. Zhao, Qianyi; Han, Xiaoyu; Wei, Yin; Shi, Min*; Lu, Yixin* “Asymmetric [3+2] Annulation of Allenes with Maleimides Catalyzed by Dipeptide-Derived Phosphines: Facile Creation of Functionalized Bicyclic Cyclopentenes Containing Two Tertiary Stereogenic Centers”, Chem. Commun. 2012, 48, 970. (IF=6.834)
13. Dou, Xiaowei; Han, Xiaoyu; Lu, Yixin* “From FeistBénary Reaction to Organo- catalytic Domino MichaelAlkylation Reaction: Asymmetric Synthesis of 3(2H)- Furanones”, Chem. Eur. J. 2012, 18, 85. (IF=5.731)
14. Zhong, Fangrui; Han, Xiaoyu; Wang, Youqing; Lu, Yixin* “Highly Enantioselective [3+2] Annulation of MoritBaylisHillman Adducts Mediated by L-Threonin- e-Derived Phosphines: Synthesis of 3-Spirocyclopentene-2-oxindole having Two Contiguous Quaternary Centers”, Angew. Chem. Int. Ed. 2011, 50, 7837  (IF=11.261)